abstract：:Experimental Doxorubicin-exposure in utero is correlated with foetal oesophageal atresia, tracheo-oesophageal fistula, axial alterations. While gastrointestinal and respiratory defects have been largely investigated, only sporadic data have been published to date on notochordal and vertebral defects. The aim of this w...

journal_title：Histology and histopathology

authors： Menegola E,Broccia ML,Di RF

更新日期：2002-01-01 00:00:00

abstract：:Terminal dendrites of cone horizontal cells (HCs) in teleost retinas show numerous spine-like protrusions named spinules, which are invaginated into the cone pedicles during light-adaptation, but retracted during dark-adaptation. Somata of HC show nematosomes whose size decreases as the number of spinules increases. M...

journal_title：Histology and histopathology

authors： García M,Grzywacz NM,De Juan J

更新日期：2002-01-01 00:00:00

abstract：:The main role of growth arrest and DNA damage-inducible (GADD) genes is to block proliferation at G1 and G2 checkpoints in response to DNA damage. The goal of this study was to examine the expression of GADD genes in primary melanomas with respect to prognosis. GADD34 was found in 73% of the primary melanomas investig...

journal_title：Histology and histopathology

authors： Korabiowska M,Cordon-Cardo C,Betke H,Schlott T,Kotthaus M,Stachura J,Brinck U

更新日期：2002-01-01 00:00:00

abstract：:STAT and SMAD often exert opposite biological effects on diverse cellular functions. Recent studies have shown that STAT can interface with SMAD at molecular level and that some novel molecules, such as SOCS (also called CIS) and APRO6 (also called TOB), modulate this signaling. A cofactor p300/CBP might act as a brid...

journal_title：Histology and histopathology

authors： Iwamoto T,Oshima K,Seng T,Feng X,Oo ML,Hamaguchi M,Matsuda S

更新日期：2002-01-01 00:00:00

abstract：:The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...

journal_title：Histology and histopathology

authors： Jin Y,Lu HB,Liong E,Lau TY,Tipoe GL

更新日期：2001-10-01 00:00:00

abstract：:E(epithelial)-cadherin is a member of a calcium-dependent family of cell surface glycoproteins involved in cell-cell adhesion and morphogenesis. Catenins are a large family of proteins that connect the cadherins to the cytoskeleton. They are important for cadherin function and for transducing signals involved in speci...

journal_title：Histology and histopathology

authors： Izaguirre MF,Adur JF,Soler AP,Casco VH

更新日期：2001-10-01 00:00:00

abstract：:Detailed histomorphometric analysis of human conjunctival biopsy specimens has convincingly demonstrated that tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with conjunctival scarring in ocular cicatricial pemphigoid (OCP). The conjunctival scarring often eventually ...

journal_title：Histology and histopathology

authors： Razzaque MS,Foster CS,Ahmed AR

更新日期：2001-10-01 00:00:00

abstract：:Orexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OX1R and OX2R. OX1R is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmol/kg body weight of orexins...

journal_title：Histology and histopathology

authors： Malendowicz LK,Jedrzejczak N,Belloni AS,Trejter M,Hochól A,Nussdorfer GG

更新日期：2001-07-01 00:00:00

abstract：:Earlier we reported that atherosclerotic lesions of apoE-deficient mice contained cells which stained positively with anti-S-100 antibody and that cells exhibiting the ultrastructural features of dendritic cells were present in the aortic lesions. These observations suggested that dendritic cells might be involved in ...

journal_title：Histology and histopathology

authors： Bobryshev YV,Taksir T,Lord RS,Freeman MW

更新日期：2001-07-01 00:00:00

abstract：:Treatment of neurodegenerative diseases by classical pharmacotherapy is restricted by blood-brain barrier which prevents access to the brain of potentially therapeutic molecules. Recent progress in the knowledge of pathophysiological molecular processes, and in the development of molecular biotechnology have opened th...

journal_title：Histology and histopathology

authors： Giménez y Ribotta M

更新日期：2001-07-01 00:00:00

abstract：:Beta-catenin expression in small cell lung carcinomas (SCLC) was investigated by immunohistochemical method using antibodies against beta-catenin. 50 pre-treatment biopsies were examined and the relationship between beta-catenin expression and the patients' relevant clinical characteristics, response to chemotherapy, ...

journal_title：Histology and histopathology

authors： Rodríguez-Salas N,Palacios J,de Castro J,Moreno G,González-Barón M,Gamallo C

更新日期：2001-04-01 00:00:00

abstract：:In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...

journal_title：Histology and histopathology

authors： Rodríguez-Gómez FJ,Rendón-Unceta MC,Piñuela C,Muñoz-Cueto JA,Jiménez-Tenorio N,Sarasquete C

更新日期：2001-04-01 00:00:00

abstract：:Transforming growth factor-betas (TGF-betas) are multifunctional cytokines that exist in 3 isoforms in mammals. The TGF-betas are ubiquitously expressed and all isoforms are secreted as biologically inactive precursors called latent TGF-beta (L-TGF-beta). L-TGF-betas are generally not effective molecules because they ...

journal_title：Histology and histopathology

authors： Khalil N

更新日期：2001-04-01 00:00:00

abstract：:A method for the in vitro generation of granulomas and its use in the analysis of the human granulomatous response is summarized. As a target for the cellular response L3 larvae of Nippostrongylus brasiliensis are coincubated with human mononuclear blood cells, and within seven to fourteen days the development of bloo...

journal_title：Histology and histopathology

authors： Seitzer U,Haas H,Gerdes J

更新日期：2001-04-01 00:00:00

abstract：:The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation has been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors ...

journal_title：Histology and histopathology

authors： Trejter M,Warchol JB,de Caro R,Brelinska R,Nussdorfer GG,Malendowicz LK

更新日期：2001-01-01 00:00:00

abstract：:Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...

journal_title：Histology and histopathology

authors： Ziman MR,Rodger J,Chen P,Papadimitriou JM,Dunlop SA,Beazley LD

更新日期：2001-01-01 00:00:00

abstract：:Osteoclasts are physiological polykaryons specialized in the resorption of calcified tissue. In the context of the clinical use of calcium-phosphate (CaP) ceramics as bone substitutes, this study used transmission electron microscopy to investigate the in vitro mechanisms of CaP ceramic degradation by osteoclastic cel...

journal_title：Histology and histopathology

authors： Heymann D,Guicheux J,Rousselle AV

更新日期：2001-01-01 00:00:00

abstract：:The sarcolemmal domain of rat duodenal smooth muscle cells includes caveolae and associated cytoskeletal or filamentous elements. We have used the quick-freezing, deep-etching method to examine the three dimensional relationships between these components. Replica membranes for separated strips of rat duodenal muscle l...

journal_title：Histology and histopathology

authors： Takayama I,Fujii Y,Terada N,Baba T,Kato Y,Fujino MA,Ohno S

更新日期：2000-10-01 00:00:00

abstract：:Nitric oxide (NO) is a widely recognized mediator of physiological and pathophysiological signal transmission. Its generation through L-arginine metabolism is relevant in the mesangium of the kidney where NO is produced by constitutive and inducible NO-synthase isoenzymes. Signaling is achieved through target interact...

journal_title：Histology and histopathology

authors： Sandau KB,Brüne B

更新日期：2000-10-01 00:00:00

abstract：:There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER...

journal_title：Histology and histopathology

authors： Pelletier G

更新日期：2000-10-01 00:00:00

abstract：:There is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic m...

journal_title：Histology and histopathology

authors： Nadorfy-López E,Torres SH,Finol H,Méndez M,Bello B

更新日期：2000-07-01 00:00:00

abstract：:Dramatical development of molecular genetics has been disclosing the molecular mechanism of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). DMD gene product, dystrophin, is a submembranous cytoskeletal protein and many dystrophin-associated proteins (DAPs) have been identified, such as utrophin,...

journal_title：Histology and histopathology

authors： Ueda H,Baba T,Ohno S

更新日期：2000-07-01 00:00:00

abstract：:In the lungs, neuronal M2 muscarinic receptors limit the release of acetylcholine from postganglionic cholinergic nerves. However, these receptors are not functional under certain circumstances in animal models of hyperreactivity such as occurs after exposure of sensitised animals to an allergen or during a respirator...

journal_title：Histology and histopathology

authors： Costello RW,Jacoby DB,Gleich GJ,Fryer AD

更新日期：2000-07-01 00:00:00

abstract：:The hindgut is the major site in the horse for nutrient digestion and absorption. Most of this activity occurs in the large intestinal compartments, i.e., cecum, right and left ventral colon and left and right dorsal colon. The colonic pelvic flexure is a short and narrow loop connecting the left ventral and left dors...

journal_title：Histology and histopathology

authors： Lopes MA,Pfeiffer CJ

更新日期：2000-07-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-1beta) has been shown to modulate both cell proliferation and the synthesis of extracellular matrix by vascular cells. This study was aimed to establish the temporal correlation between TGF-beta1 expression, the expression of the extracellular matrix protein fibronectin, and plaqu...

journal_title：Histology and histopathology

authors： Chen YL,Wu HW,Jiang MJ

更新日期：2000-04-01 00:00:00

abstract：:The nerve fiber distribution in the epidermis of the hairless rat skin was studied light microscopically by means of zinc iodide-osmium tetroxide staining. Two different morphological types of free nerve fiber endings could be detected: clusters of relatively thick nerve fibers stretched up through the spinous layer u...

journal_title：Histology and histopathology

authors： Müller T

更新日期：2000-04-01 00:00:00

abstract：:CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within th...

journal_title：Histology and histopathology

authors： Mamoune A,Durand V,Le Goff P,Pennec YL,Youinou P,Le Corre R

更新日期：2000-04-01 00:00:00

abstract：:To determine the appropriate time for bone reconstruction after irradiation, the healing process after autogenous iliac bone transplantation in the irradiated parietal bone was examined by scanning electron microscopy and light microscopy. Bone transplantation was carried out at the second and the fourth weeks after C...

journal_title：Histology and histopathology

authors： Takekawa M,Matsuda M,Ohotubo S

更新日期：2000-01-01 00:00:00

abstract：:The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index...

journal_title：Histology and histopathology

authors： Ortiz PP,Sarrat R,Daret D,Whyte J,Torres A,Lamazière JM

更新日期：2000-01-01 00:00:00

abstract：:Macrophages are important effector cells in cell-mediated immunity against intracellular infection. Among cytokines that macrophages are able to release are IL-12 and TNF alpha. IL-12 is a critical linker between the innate and adaptive cell-mediated immunity, capable of Th1 differentiation and IFN gamma release by T ...

journal_title：Histology and histopathology

authors： Xing Z

更新日期：2000-01-01 00:00:00

abstract：:In the cutaneous nerves, unmyelinated nerve fibers outnumber the myelinated ones but are scarcely analyzed, especially at autopsy. This indifference toward the pathology of unmyelinated nerve fibers may be due to the necessity of electron microscopic analyses and, more importantly, the obscurity of pathological altera...

journal_title：Histology and histopathology

authors： Kanda T

更新日期：2000-01-01 00:00:00

abstract：:The effect of prolonged exposure to normobaric hypoxia on the mitochondria of myocard of rats exposed for several weeks to 8 and 7% O2 has been morphometrically evaluated. Twelve male Wistar rats housed in Nalgene cages (2 per cage) with a batch of six cages placed in plexiglass chambers were maintained in air/N2 mixt...

journal_title：Histology and histopathology

authors： Cervós Navarro J,Kunas RC,Sampaolo S,Mansmann U

更新日期：1999-10-01 00:00:00

abstract：:An ultrastructural and histological study was made to analyse the structural and cellular features of the pulmonary lesions produced in Wistar rats by intraperitoneal (i.p.) administration of cyclophosphamide (two i.p. doses of 150 mg CP/1 kg bw/1 ml PBS). Rats exposed to cyclophosphamide (CP) developed a condition wh...

journal_title：Histology and histopathology

authors： Sulkowski S,Sulkowska M

更新日期：1999-10-01 00:00:00

abstract：:Bone marrow features in stable-phase chronic myelogenous leukemia (CML) are characterized by a striking heterogeneity which is determinable by appropriate means including representative pre-treatment trephine biopsies, immunohistochemistry and morphometry. Cell lineages involved to a variable extent consist not only o...

journal_title：Histology and histopathology

authors： Thiele J,Kvasnicka HM,Fischer R

更新日期：1999-10-01 00:00:00

abstract：:Systematic studies on hepatic stellate cells and myofibroblasts have so far mainly focused on cells located in the perisinusoidal space of Disse, the so-called littoral compartment. Here, these cells play a key role for intralobular fibrogenesis and sinusoidal capillarization. However, advanced hepatic fibrosis and ci...

journal_title：Histology and histopathology

authors： Zimmermann A,Zimmermann H,Fellay M,Reichen J

更新日期：1999-07-01 00:00:00

abstract：:Unlike other B cells, plasma cells (PC) react with only a few antibodies against haemopoietic antigens. We investigated 36 specimens exhibiting a reactive increase in PC numbers (i.e. plasmacytosis, PC hyperplasia) with a broad panel of antibodies suitable for use on formalin-fixed, paraffin-embedded tissue, and compa...

journal_title：Histology and histopathology

authors： Beschorner R,Horny HP,Petruch UR,Kaiserling E

更新日期：1999-07-01 00:00:00

abstract：:Glucose uptake and metabolism are essential for proliferation and survival of cells, and are supposed to be enhanced in actively proliferating cell systems such as embryonic and cancer tissues. Glucose uptake is usually carried out through glucose transporters. In the developing fetal lung, metabolism of glucose is th...

journal_title：Histology and histopathology

authors： Ito T,Noguchi Y,Udaka N,Kitamura H,Satoh S

更新日期：1999-07-01 00:00:00

abstract：:The anti-oxidant food additive, butylated hydroxytoluene (BHT), was fed to Sprague-Dawley rats at three concentrations: 0.2%, 0.4% and 0.8% for periods of 6, 12, 18 and 24 weeks, and the results were compared with corresponding groups treated with a potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) groups, with...

journal_title：Histology and histopathology

authors： Safer AM,al-Nughamish AJ

更新日期：1999-04-01 00:00:00

abstract：:The presence of Cajal-Retzius cells in the adult human prefrontal and visual cortices has been demonstrated with calcium binding protein immunocytochemistry and NADPH-diaphorase histochemistry. These cells expressed parvalbumin, calbindin and calretinin calcium binding proteins and displayed NADPH-diaphorase enzyme ac...

journal_title：Histology and histopathology

authors： Martín R,Gutiérrez A,Peñafiel A,Marín-Padilla M,de la Calle A

更新日期：1999-04-01 00:00:00

abstract：:Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...

journal_title：Histology and histopathology

authors： Chiang TM

更新日期：1999-04-01 00:00:00